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bioscience schreef op 19 mei 2017 14:47 :
[...]
Volgens mij vergeet je 1 zaak mbt Ablynx .
Ablynx zit veel dichter bij goedkeuring/ marktintroductie van een eerste medicijn dan GLPG . Al denk ik dat GLPG een grote toekomst tegemoet gaat staan ze wat koers tov Ablynx veel te hoog (tevens weet je niet wat fase 3 gaat doen) . Dat heeft te maken door dat de grote hoop (op dit moment)achter GLPG aan hobbelt en Ablynx (ook uiteraard door stomme fouten/lees contract met Abbvie)) in de vergetelheid is geraakt . Dit kan echter zeer snel bijtrekken .
Ik zet iig in op Ablynx / Argen-X en Thrombogenics . Alle 3 zeer laag gewaardeerd als we het afzetten tegenover pipeline en cash .
Ik heb helemaal niets over Ablynx gezegd, dus ben ook niks vergeten ... :-)
Geen probleem hoor P14 . Maar volgens mij schrijf je toch duidelijk dat je de helft van Ablynx heb verkocht en daar GLPG voor heb terug gekocht . Indien je GLPG heb gekocht op 10 euro nog niet zo heel lang geleden , dan heb je het heel goed gedaan . Nu kan je Ablynx kopen voor nog geen 11 euro en die gaat sneller met een product op de markt komen dan GLPG zoals het er nu uitziet . Marktwaardes as we speak Ablynx 673 miljoen GLPG 3920 miljoen Argen-x 385 miljoen prettig weekend
bioscience schreef op 19 mei 2017 18:04 :
Geen probleem hoor P14 . Maar volgens mij schrijf je toch duidelijk dat je de helft van Ablynx heb verkocht en daar GLPG voor heb terug gekocht . Indien je GLPG heb gekocht op 10 euro nog niet zo heel lang geleden , dan heb je het heel goed gedaan . Nu kan je Ablynx kopen voor nog geen 11 euro en die gaat sneller met een product op de markt komen dan GLPG zoals het er nu uitziet .
Marktwaardes as we speak
Ablynx 673 miljoen
GLPG 3920 miljoen
Argen-x 385 miljoen
prettig weekend
Volgens mij schrijft KAKO dat duidelijk, niet ik.. Daarnaast zit ik wel al lang in Gala, maar helaas niet vanaf 10 euro. Mijn overtuiging is echter wel dat de potentie van Gala groter is dan die van Abblynx, getuige de beurskoers.
Vreemd . Koers in USA 20,88 dollar = 18,53 euro Koers wordt hier met laag volume gedrukt lijkt het . Je zou zeggen dat de koers in de USA gemaakt wordt met een veel hoger volume .
Van Herk verzilvert voor 8 miljoen biotechaandelen ArgenXwww.rtlnieuws.nl/geld-en-werk/van-her...
Dat heeft hij al gedaan weken geleden . De andere helft heeft hij dus gratis nog in portefeuille . Heeft ie goed gedaan . Ik hou ze gewoon lekker vast .
www.tijd.be/markten-live/nieuws-aande... Argen-x staat er heel goed voor in het rijtje
Argen-X gooit hoge ogen in USA Upgrade van 2 beursbedrijven heisenbergreport.com/2017/06/12/key-c... www.streetinsider.com/New+Coverage/JM... JP Morgan 33 US$ Cowen Outperform BAH Buy and Hold
Kleine correctie, het is niet JP Morgan, maar JMP Securities dat met de $33 dollar koers komt.
Pokerface schreef op 13 juni 2017 18:03 :
Kleine correctie, het is niet JP Morgan, maar JMP Securities dat met de $33 dollar koers komt.
yes .
Published: 08:00 CEST 14-06-2017 /GlobeNewswire /Source: argenx SE / : ARGX /ISIN: NL0010832176 argenx presents update on Phase I data from ARGX-110 expansion study in patients with cutaneous T-cell lymphomas at the International Conference of Malignant Lymphoma (ICML) June 14, 2017 Breda, the Netherlands / Ghent, Belgium - argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, today presented updated data from its Phase 1b expansion study of ARGX-110 in patients with different subtypes of relapsed/refractory cutaneous T-cell lymphoma (CTCL) and various disease stages, at the International Conference of Malignant Lymphoma (ICML) in Lugano, Italy. "Analysis of the skin biopsies continues to strengthen the biological rationale of targeting CD70 with ARGX-110. Clinical activity was observed in patients across different CTCL subtypes (mycosis fungoides, Sézary syndrome, panniculitis-like TCL) and different disease stages whilst the drug shows a favorable safety and tolerability profile," commented Nicolas Leupin, Chief Medical Officer of argenx. "Improved pruritis was observed in some of the patients and will be further monitored to explore ARGX-110 modes of action in skin of CTCL patients." The updated data from the currently ongoing Phase Ib study continue to show evidence of clinical and/or biological anti-tumor activity with ARGX-110. We observed partial response and stable disease, respectively, in three and seven out of 16 patients with highly relapsed/refractory CTCL and confirmed overexpression of CD70. Treatment-emerging adverse events were reported for six out of 16 patients. The poster presented at ICML can be accessed from the "Downloads" section of the argenx website. In April 2017, argenx announced the initiation of a Phase II trial of ARGX-110 as a monotherapy in relapsed/refractory CTCL patients, in order to further examine the activity of the product candidate, using the optimal dose and biomarker panel determined during the Phase Ib trial. About ARGX-110 ARGX-110 is a SIMPLE Antibody(TM) targeting CD70, an immune checkpoint target involved in hematological malignancies, several solid tumors and severe autoimmune diseases. ARGX-110 is designed to: i) block CD70, ii) kill cancer cells expressing CD70 through antibody-dependent cellular phagocytosis and iii) restore immune surveillance against solid tumors (Silence K. et al. mAbs 2014; 6 (2):523-532). ARGX-110 is currently being evaluated in patients with hematological and solid tumors. ARGX-110 is currently being evaluated in a Phase II trial in combination with azacitidine in patients with newly diagnosed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) and a Phase II trial in patients with relapsed/refractory CTCL. Preclinical work on ARGX-110 in AML was performed in collaboration with the Tumor Immunology Lab of Prof. A. F. Ochsenbein at the University of Bern, who won, together with Prof. Manz from the University Hospital of Zürich, the prestigious 2016 Otto Naegeli Prize for his breakthrough research on CD70/CD27 signaling with therapeutic potential for cancer patients. About argenx argenx is a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer. We are focused on developing product candidates with the potential to be either first-in-class against novel targets or best-in-class against known, but complex, targets in order to treat diseases with a significant unmet medical need. Our ability to execute on this focus is enabled by our suite of differentiated technologies. Our SIMPLE Antibody(TM) Platform, based on the powerful llama immune system, allows us to exploit novel and complex targets, and our three antibody engineering technologies are designed to enable us to expand the therapeutic index of our product candidates. www.argenx.com
Hoe moet ik dit interpreteren? Goed of slecht? Ik schrik van die 6 van de 16 patiënten met 'adverse events'. Maar misschien stelt dat niks voor.
Goed uiteraard . Gooi hem maar door Google translate . Dit is een onderzoek in vele varianten met verschillende subtypes van recidiverend / refractair kutan T-cellymfoom (CTCL) en diverse ziektefasen bij de Internationale Conferentie van Malignant Lymfoom (ICML) Hieruit worden dan in later stadium de varianten gekozen die het beste werkt bij dat type . Er is werking en het is veilig . Nieuwe fase worden of zijn al opgestart in april : In april 2017 kondigde argenx de aanvang van een fase II trial van ARGX-110 als een monotherapie bij recidiverende / refractaire CTCL-patiënten aan, om de activiteit van de productkandidaat verder te onderzoeken met behulp van de optimale dosis en biomarkerpaneel bepaald tijdens de fase Ib trial.
Overigens gisteren in de USA op 21,30$ = 19,03 euro gesloten . Moet dus wel positief zijn toch.
Ik snap van heel die prijsstelling(USA/Europa) weinig meer . USA sluit vrijdag op 20,98 dollar= 18,72 euro . Terwijl het die dag nog de 21,77 dollar= 19,43 euro heeft aan getik. Hier opent het bij een positieve beurs 18,45 euro .
Published: 07:00 CEST 20-06-2017 /GlobeNewswire /Source: argenx SE / : ARGX /ISIN: NL0010832176 argenx receives second preclinical milestone payment in collaboration with LEO Pharma June 20, 2017 Breda, the Netherlands / Ghent, Belgium - argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, today announced the achievement of the second of two preclinical milestones in connection with its collaboration with LEO Pharma. "Our collaboration with LEO Pharma continues to be highly productive with the announcement of this most recent preclinical milestone. This achievement is the second of two success-based preclinical milestones with the first having been received last year. We continue to be excited about the potential of ARGX-112 in inflammatory skin diseases and are optimistic that the collaboration may yield a clinical program in the near future," commented Tim Van Hauwermeiren, CEO at argenx. In May 2015, argenx entered into a research collaboration and exclusive license option agreement with LEO Pharma to develop and commercialize ARGX-112, a novel antibody program discovered by argenx using its SIMPLE Antibody(TM) technology. Under the terms of that agreement, argenx is responsible for conducting ARGX-112 research and development activities up to a first filing by LEO Pharma for clinical trial application approval. Based on its well-differentiated therapeutic profile, ARGX-112 is anticipated to have exciting development potential for inflammatory skin disorders such as atopic dermatitis. argenx has granted LEO an exclusive option to obtain a worldwide, exclusive license to the ARGX-112 program, to develop and commercialize licensed products for inflammatory skin disorders. In addition to the upfront and first preclinical milestone payments already received, argenx may receive further regulatory and clinical milestone payments up to approximately €100mm as well as royalties on net sales of any products. About argenx argenx is a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer. We are focused on developing product candidates with the potential to be either first-in-class against novel targets or best-in-class against known, but complex, targets in order to treat diseases with a significant unmet medical need. Our ability to execute on this focus is enabled by our suite of differentiated technologies. Our SIMPLE Antibody(TM) Platform, based on the powerful llama immune system, allows us to exploit novel and complex targets, and our three antibody engineering technologies are designed to enable us to expand the therapeutic index of our product candidates. www.argenx.com For further information, please contact: Joke Comijn, Corporate Communications Manager +32 (0)477 77 29 44 +32 (0)9 310 34 19info@argenx.com Beth DelGiacco (US IR) Stern Investor Relations +1 212 362 1200beth@sternir.com
USA gisteren gesloten op 20,93$ = 18,39 + 5% hier gewoon weer lekker minnen
Knap hoor . Slot gisteren USA 20,76 = 18,21 euro
En wederom . slot gisteren USA $ 20,67 = 18,19 euro
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