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MOR103 (PerC6 inside) PHASE I
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Voor degenen die het niet weten. MOR103 Program = PER.C6 inside.
Zag net dat Flosz het al eerder gepost had : Goede morgen..... MorphoSys Announces Completion of First Dosing in Phase 1 Trial for MOR103 Program Per.c6 inside! 04/28/2008 at 07:30 AM viewtopic.php?f=8&t=107&p=7319#p7319 flosz Moderator Berichten: 2081 Geregistreerd op: do maart 01, 2007 22:42
Het staat op zich ook wel redelijk aardig duidelijk zichtbaar in de titel.
SJC schreef:
Het staat op zich ook wel redelijk aardig duidelijk zichtbaar in de titel.
En toch schijnt het belang niet door te dringen van de posting van gocrucellgo. Voortgang in de pipeline van de licentienemers. Als de eerste producten op basis van per.c6 op de markt gaan komen dan wordt het echt leuk.
door flosz op di apr 29, 2008 6:48 MorphoSys AG Reports First Quarter 2008 Results 04/29/2008 at 07:30 AM Revenues up 16 %, Operating Profit Tripled MorphoSys AG (FSE: MOR; Prime Standard Segment; TecDAX) today announced its financial results according to International Financial Reporting Standards (IFRS) for the first quarter ending March 31, 2008. Group revenues increased by 16 % to EUR 16.3 million (Q1 2007: EUR 14.1 million) and operating profit tripled to EUR 4.1 million (Q1 2007: EUR 1.3 million). Net profit amounted to EUR 3.3 million (Q1 2007: EUR 0.6 million). At the end of the first quarter of 2008 MorphoSys's cash position amounted to EUR 111.8 million (December 31, 2007: EUR 106.9 million). Highlights of the First Quarter of 2008: • MorphoSys received approval from regulatory authorities in the Netherlands to initiate a phase 1 clinical study for its proprietary therapeutic program MOR103. MOR103 is a fully human HuCAL antibody directed against GM-CSF (granulocyte macrophage colony-stimulating factor), being developed in the area of inflammatory diseases, such as rheumatoid arthritis. The phase 1 trial started as planned and the first dosing regimen in healthy volunteers was already completed. • MorphoSys signed a PER.C6® license agreement with Dutch biotechnology company Crucell N.V. and technology partner DSM Biologics. This license agreement allows MorphoSys to use the PER.C6® cell line in the production of clinical grade material for the development of its proprietary therapeutic cancer antibody program MOR202. • The therapeutic partnerships with Astellas as well as with Daiichi Sankyo were extended to run their full course. • Partnered pipeline grew to 54 active therapeutic antibody projects (up from 50 at the end of 2007); number of pre-clinical candidates remained constant at 23. • MorphoSys signed a collaboration agreement with Sigma-Aldrich to design, produce and distribute unique recombinant research antibodies using MorphoSys's proprietary HuCAL GOLD technology. • MorphoSys's business unit AbD Serotec has received a multiple research antibody order from Proteomika SL, a Spanish biotechnology company specializing in biomarker discovery. The order ranks Proteomika among the largest customers for custom monoclonals services provided by AbD Serotec. • MorphoSys's collaboration with Novartis has been recognized as the "European Pharma Deal of the Year" in Sachs Associates' Life Science Innovation Awards. "The first quarter aptly demonstrates continued growth and increasing profitability for both lines of our business." commented Dave Lemus, Chief Financial Officer of MorphoSys AG. "As targeted, the AbD segment has begun its swing into financial profitability for the year, and we expect increased milestone payments on the therapeutic side of our business in coming quarters to help support higher levels of revenues, profits and proprietary product investment."www.morphosys.com/en/news_invest ... e-604.html ********************************** Progress Proprietary Pipeline MOR103 In January 2008, MorphoSys announced an agreement with the University of Melbourne providing MorphoSys with exclusive access to rights covering the use of inhibitors of GM-CSF under a U.S. patent application and its progeny. MorphoSys believes that the University of Melbourne’s patent applications, once allowed, will lead to market exclusivity for therapeutic antibodies targeting GMCSF for anti-inflammatory indications in the U.S., which represents the lion's share of the total rheumatoid arthritis (RA) market. In 2004, the market for biopharmaceuticals to treat RA amounted to US$ 6 billion worldwide and is expected to further increase to US$ 14 billion in 2009. The University of Melbourne receives an upfront payment, milestone payments associated with clinical development and royalty payments based on net sales of products in the U.S. In addition to the intellectual property rights secured under the agreement with the University of Melbourne, MorphoSys has filed additional patent applications on the antibodies it has generated in its MOR103 program. In February 2008, MorphoSys announced that the regulatory authorities in the Netherlands have approved the clinical trial application (CTA) to initiate a phase 1 study of the HuCAL-derived antibody MOR103. MorphoSys had submitted the clinical trial application in December 2007. In parallel, MorphoSys has received a manufacturing license from the Bavarian government, allowing MorphoSys to release clinical trial material for MOR103 clinical studies as a sponsor. In our Therapeutic Antibodies segment, significant progress was made both on the partnered and proprietary side of the business. With regard to our proprietary pipeline, we advanced our lead program MOR103 according to plan. Following the CTA filing in December 2007, we received approval from Dutch authorities within six weeks. In the interim, a phase 1 trial has been initiated; the first dosing regimen is completed. Thereby the drug candidate has become the fifth HuCAL antibody in the clinic. Early in 2008, we announced that the underlying target molecule is granulocyte macrophage-colony stimulating factor, also known as GM-CSF. At the same time, we disclosed an exclusive in-licensing agreement on a fundamental U.S. patent application involving GM-CSF as a means of treating inflammatory diseases. We expect this license to allow Morpho- Sys an exclusive position on marketing rights for therapeutic antibodies targeting GM-CSF in the U.S., the largest market for arthritis treatment. On the partnered side of our therapeutic business, we saw the extension of two alliances with leading pharmaceutical companies in Japan, more specifically, Astellas and Daiichi Sankyo. Both companies decided to continue our partnerships thereby securing access to our technology using pre-existing options to extend the contract till 2012 and 2011, respectively. Research and Development Expenses Expenses for research and development increased by € 0.4 million to € 5.3 million (Q1 2007: € 4.9 million) mainly due to higher personnel costs (Q1 2008: € 2.4 million; Q1 2007: € 1.9 million) and increased costs for intangibles (Q1 2008: € 1.4 million; Q1 2007: € 1.0 million) which were partly offset by a decrease in costs for external services (Q1 2008: € 0.3 million; Q1 2007: € 0.8 million). The two proprietary products currently being internally developed by MorphoSys are MOR103 and MOR202. In the first three months of 2008, the Company incurred costs for proprietary product development and technology development in the amount of € 0.8 million and € 0.3 million, respectively (Q1 2007: € 1.0 million and € 0.2 million, respectively).212.14.81.205/uploads/MOR_Q1-2008_e.pdf MorphoSys First-Quarter Net Rises Fivefold on Novartis Payment MorphoSys AG, the German biotechnology company working with Novartis AG, said first- quarter profit rose more than fivefold on payments from its drug development partners.www.bloomberg.com/apps/news?pid= ... er=germany 04/29/2008 - Three Months 2008 Results MorphoSys will publish its first three months’ 2008 results on April 29, 2008 at 7:30 a.m. CEST. At 10:00 a.m. CEST, the Management Board of MorphoSys AG will host a public conference call to present MorphoSys’s financial results for the first three months of 2008 and provide further details on the Compan
Event: Deutsche Bank 33rd Annual Health Care Conference View the Webcastwww.morphosys.com/en
gocrucellgo schreef:
Event: Deutsche Bank 33rd Annual Health Care Conference
View the Webcast
www.morphosys.com/en MPSYY.PK - Morphosys AG EVENT TITLE Morphosys AG at Deutsche Bank Securities Inc. Health Care Conference DATE / TIME Tuesday, May 6, 2008 2:50 PM ET Zie vooral slide 13 t/m. 16 10:21webcastingplayer.corporate-ir.net/pla...
preclinical data presentatie dus gepland midden dit jaar.
Schering-Plough Extends Antibody Alliance with MorphoSys 05/19/2008 at 07:30 AM Third Extension with Major Pharmaceutical Company after Landmark Deal with Novartis MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that Schering-Plough Corporation has decided to extend the current collaboration between the two companies for one year. The collaboration, announced in May 2006, has a maximum term of 5 years until 2011 and may be extended by Schering-Plough after each single year. Under the agreement, Schering-Plough will continue to have access to MorphoSys's proprietary antibody library HuCAL GOLD at its research site in Palo Alto, California, the location of Schering-Plough Biopharma, an affiliate of Schering-Plough Research Institute. Furthermore, the contract provides Schering-Plough with the option to develop and commercialize HuCAL-derived therapeutic antibodies, in which case MorphoSys would receive exclusive license fees, milestone payments, as well as royalties. Under the extended agreement MorphoSys continues to receive annual user fees for access to its HuCAL platform. Further financial details were not disclosed. "Today's news is yet another clear signal that our HuCAL technology will continue to form the basis of antibody-based drug development programs at a number of leading pharmaceutical companies," commented Dr. Simon Moroney, Chief Executive Officer of MorphoSys. "We are very pleased with Schering-Plough's decision to continue using our HuCAL GOLD technology for their antibody development programs." For further information please contact: Dr. Claudia Gutjahr-Löser, Head of Corporate Communications & Investor Relations, Tel: +49 (0) 89 / 899 27-122, gutjahr-loeser@morphosys.com or Mario Brkulj, Manager Corporate Communications & Investor Relations, Tel: +49 (0) 89 / 899 27-454, brkulj@morphosys.com www.morphosys.com/en/news_investors/p...
A well diversified Biotech Morphosys develops therapeutic and research antibodies for commercialisation and for its own account. Through a close collaboration with Novartis, Morphosys is well financed to buildup an internal drug development pipeline while remaining profitable. We believe the company to be significantly undervalued and see Morphosys’ fair value at EUR 80. Partnered antibodies programs: 54 partnered programs (4 in clinical, 23 in preclinical and 27 in discovery development). If everything goes well Morphosys is to receive up to EUR 12m in milestone payments and c. 5% royalties on product sales for an average program. Novartis deal: Committed payments of USD 600m over 10 years. One half of this amount will be devoted to Morphosys’ research funding, while the other half are technology license fees. Success-based milestones on products development could bring additional USD 400m in milestones. Moreover, MOR is entitled to royalty payments in the midsingle digits. Proprietary antibodies programs: MOR103 (Phase I) and MOR202 (Preclinical) primarily targeting rheumatoid arthritis and Multiple Myeloma are well on track towards the next development stages. Strong Q1 2008 results: Sales increased by 16% to EUR 16.3m. Driven by higher levels of funded research and licensing fees from Novartis. A 5% decrease in operating expenses allowed group EBIT to surge by 215% to EUR 4.1m. EPS rose from EUR 0.09 to EUR 0.44 Triggers: 1) Clinical proof of concept data of a MOR Alzheimer antibody developed by Roche in H2 2008e. 2) MOR might receive a payment of c. EUR 30m - that is not included in our forecasts - for the internalization of MOR Hucal technology at Novartis in ‘08e or ‘09e. Valuation: Primarily based on a SOTP approach we see Morphosys’ fair value at EUR 80 per share. Please note that the current market cap equals more or less Morphosys’ net cash position and committed cash flows over the next nine years from Novartis. Hence, the Hucal technology and the antibody pipeline are more or less for free. Martin Possienke, CEFA Equinet +49 69 58997 412martin.possienke@equinet-ag.de Edouard Aubery Equinet +49 69 58997-439edouard.aubery@equinet-ag.de
OncoMed Pharmaceuticals Extends License Agreement for Use of MorphoSys's Core Technology 06/16/2008 at 07:30 AM Parties Initiate First Fully Human Antibody Programs Targeting Cancer Stem Cells MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that U.S. based biopharmaceutical company OncoMed Pharmaceuticals, Inc. has triggered its pre-existing option to extend the current license agreement between the two companies and has initiated two therapeutic antibody development programs targeting cancer stem cells. Under the extended agreement, which now runs until June 2010, MorphoSys continues to grant OncoMed access to its proprietary antibody library HuCAL GOLD for the use in the research and development of human therapeutic antibodies for the treatment of various cancers by targeting cancer stem cells. The extended agreement includes annual user fees to MorphoSys for OncoMed's access to the HuCAL platform. The two-year extension includes an option for OncoMed to develop and commercialize up to 3 additional HuCAL-derived therapeutic antibodies. In all cases MorphoSys stands to receive exclusive license fees, milestone payments, as well as royalties on end products. Further financial details were not disclosed. Founded in August 2004, OncoMed Pharmaceuticals is discovering and developing monoclonal antibodies and proteins capable of eliminating "cancer stem cells", which are believed to play a key role in the establishment, metastasis and recurrence of cancer. OncoMed is at the forefront of applying research from the University of Michigan to isolate, purify, and analyze cancer stem cells. The company has established a large library of antibodies as well as proteins capable of binding to the cell surface proteins expressed on cancer stem cells and inhibiting cancer stem cell growth. Recently OncoMed has established a strategic alliance to discover, develop and market novel cancer stem cell antibody therapeutics with GlaxoSmithKline. "We have been very successful in developing antibodies that show great promise in treating cancer," stated Paul Hastings, Chief Executive Officer of OncoMed. "The HuCAL technology has proven to be an effective tool for generating these antibodies and we are pleased to be able to continue our productive relationship with MorphoSys." "Our core HuCAL technology continues to deliver new therapeutic antibody candidates," commented Dr. Simon Moroney, Chief Executive Officer of MorphoSys. "We are excited about these programs with OncoMed, which have the potential to revolutionize cancer therapy. Today's news continues a series of extensions with existing partners who have the ability to terminate or extend collaborations through pre-existing options. This clearly demonstrates the ongoing commitment by all of our partners to bring innovative HuCAL-based antibody drugs to patients."www.morphosys.com/en/news_investors/p...
Ik plak 'm hier even bij...er was ooit een Sigma-draad, waar ?, geen flauw idee. Sigma-Aldrich Under Five Year Agreement, Academic Steering Committee will Identify Antibody Targets in the Areas of Cancer, Stem Cell and Autoimmune Research to be Produced by Sigma-Aldrich ST. LOUIS, June 19 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today announced it has entered into a five-year collaboration to develop optimal cell lines for the production of monoclonal antibodies. Scientists at the University of California, San Francisco will lead the research into antibodies for a variety of cancer targets, autoimmune diseases, stem cell characteristics and commonly neglected disease targets. Under the terms of the agreement, research targets will be determined by a steering committee composed of leading scientists at UCSF, including Lewis Lanier, Ph.D. Professor and Vice Chair, Department of Microbiology & Immunology; Jeffrey Bluestone, Ph.D. Director, UCSF Diabetes Center; and Susan Fisher, Ph.D. Professor, Department of Cell & Tissue Biology. The committee will direct research into antibodies for cancer targets, stem cell surface markers and autoimmune disease targets. The University will have free access to the antibodies resulting from the partnership for its ongoing immunology and disease research. "Sigma-Aldrich is committed to developing the most comprehensive and highly validated collection of monoclonal antibodies available for the cell biology research community," said Dr. David Smoller, President of Sigma-Aldrich's Research Biotech Business Unit. "By partnering with the highly regarded UCSF research team, Sigma-Aldrich is helping to further promote the study of a number of important cancer targets, regenerative medicine applications and neglected diseases." Sigma-Aldrich is expanding its antibody content offering as part of its plan to become a leading developer and manufacturer of the next generation of monoclonal antibody products for life science researchers. Earlier this year, the company announced a partnership to distribute the highly-validated Prestige antibodies powered by Atlas Antibodies, the commercial arm of the Human Proteome Resource. Sigma-Aldrich is also collaborating with AbD Serotec, a Division of MorphoSys, to design, produce and distribute unique recombinant research antibodies using MorphoSys's proprietary HuCAL GOLD technology.www.corporate-ir.net/ireye/ir_site.zh... *************************** Sigma developed a medium optimized for the growth of Per.C6® cells and designed to meet the regulatory needs of manufacturers for the production of biotherapeutic agents.www.sigmaaldrich.com/sigma/general%20... Alliances with manufacturing contractors :Sigma-Aldrich Corp. Dec. 2003 PER.C6® Medium development MorphoSys signed a collaboration agreement with Sigma-Aldrich to design, produce and distribute unique recombinant research antibodies using MorphoSys's proprietary HuCAL GOLD technology.www.morphosys.com/en/news_investors/p...
Boehringer Ingelheim Gains Access to Additional MorphoSys Technology 07/09/2008 at 07:30 AM MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that Boehringer Ingelheim has exercised a pre-existing option to use MorphoSys's proprietary RapMAT technology for faster antibody optimization as part of the existing technology transfer agreement between the two companies. As a result, Boehringer Ingelheim will have access to MorphoSys's RapMAT technology module alongside the existing installation of the Company's proprietary antibody library HuCAL GOLD at Boehringer Ingelheim's research site in Vienna, Austria. Under the extended agreement, MorphoSys will receive annual user fees for the RapMAT technology and for access to its HuCAL platform. Financial details were not disclosed. RapMAT, which stands for "rapid maturation", improves the options for identifying antibodies from the HuCAL libraries and reduces the time for generation of promising therapeutic lead molecules. The RapMAT technology is completely compatible with the HuCAL GOLD antibody library. MorphoSys believes that the use of RapMAT can greatly speed up antibody drug discovery, while widening the pool of drug candidates from which to choose. Under the framework of the present five-year agreement, Boehringer Ingelheim has the option to receive multiple exclusive licenses on new therapeutic antibody programs. Today, the collaboration encompasses four active therapeutic antibody programs in various indications. Two new programs have been started recently and HuCAL-derived antibodies are currently being optimized at MorphoSys on behalf of Boehringer Ingelheim. "As part of our internal antibody generation process at MorphoSys, RapMAT has already led to earlier achievement of milestones in partnered programs. We thus welcome Boehringer Ingelheim's decision to broaden its technological portfolio and use our RapMAT technology module to speed up their internal drug development process as well," commented Dr. Simon Moroney, Chief Executive Officer of MorphoSys. "Boehringer Ingelheim is an important partner; the collaboration has resulted to date in promising drug candidates for various therapeutic areas."www.morphosys.com/en/news_investors/p...
MorphoSys and Integrated BioTherapeutics Provide Update Regarding USAMRIID Biodefense Project Jul 15, 2008 AbD Serotec, a division of MorphoSys AG, announced today that its customer, US-based Integrated BioTherapeutics Inc. (IBT), has received a five-year, NIH research grant to develop human antibody therapeutics against staphylococcal enterotoxin B, a bacterial-derived toxin from Staphylococcus aureus. The project is a continuation of a biodefense-related project initiated by USAMRIID, an organization of the U.S. Army Medical Research and Materiel Command, in September 2006 using AbD Serotec’s custom monoclonal antibody services. Under the terms of the agreement, IBT will use a selection of HuCAL-based antibodies originally generated by AbD Serotec against staphylococcal enterotoxin B in in vitro and in vivo experiments to identify lead neutralizing candidates and is expected to order additional antibody material as well as other services offered by AbD Serotec. Financial details of the agreement were not disclosed. Staphylococcal enterotoxins are involved in a variety of human pathologies ranging from hospital and community-acquired infections, sepsis, toxic shock syndrome, to atopic dermatitis. Staphylococcal enterotoxin B is also considered as a potential agent of bioterrorism. Currently no vaccines or immunotherapeutics are available against staphylococcal toxins or S. aureus infections. The research collaboration between IBT and AbD Serotec follows a novel paradigm in the fight against these pathogens by targeting toxins released by bacteria which can distract the immune system and cause massive and even fatal damage. ”This grant allows us to continue a very promising project initiated by USAMRIID and AbD Serotec,” said Dr. M. Javad Aman, President and CSO of IBT, “IBT is extremely pleased to have access to AbD’s unique technology for developing antibodies with therapeutic potential in this important medical area.” “Today’s news marks yet another promising development of a pre-existing customer relationship of AbD Serotec,” comments Dr. Achim Knappik, Head of R&D at AbD Serotec. “We look forward to work with Integrated BioTherapeutics on this promising project in the field of infectious diseases which is an interesting research market for AbD Serotec.”www.morphosys.com/en/news_investors/c...
First AbD Serotec generated HuCAL Antibodies Distributed as Part of Clinical Diagnostic Kits for Autoimmune Diseases by Phadia 07/17/2008 at 07:30 AM MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that Phadia AB, a world leader in autoimmunity and allergy testing, has implemented a series of HuCAL-based recombinant antibodies in its marketed autoimmune tests Varelisa(TM) and EliA(TM). Thereby Phadia becomes the first diagnostic company to introduce recombinant antibodies in an autoimmune screening platform. AbD Serotec, MorphoSys's division for research and diagnostic antibodies, receives license fees and will continuously supply Phadia with recombinant antibody material. Further financial details were not disclosed. Phadia and AbD Serotec began collaborating in September 2005, bringing together Phadia's expertise in the development, manufacturing and marketing of complete blood test systems and AbD Serotec's leading recombinant antibody technology HuCAL. AbD Serotec has generated a series of recombinant antibodies in the IgA, IgM and IgG1 format, which Phadia will implement in its marketed autoimmune tests Varelisa(TM), a classical ELISA microtiter platform, and the fully automated system for the measurement of autoantibodies EliA(TM). The set of recombinant HuCAL antibodies provided by AbD Serotec act as recombinant control antibodies and replace human serum to standardize autoimmune assays. Autoimmune diseases include juvenile diabetes, various forms of rheumatism, hepatitis, thyroiditis and a variety of skin diseases. An early diagnosis can improve the treatment options and increase the quality of life for patients significantly. However, since the early symptoms, especially of systemic autoimmune diseases like rheumatoid disorders, can be very diffuse, several years can pass from the onset of the disease until a correct diagnosis is made. New easy-to-use and cost-effective diagnostic methods could shorten the time-to-diagnosis and subsequent treatment. "Phadia has a long track record in using advanced techniques such as recombinant gene technology to produce a wide range of precise and reliable diagnostic tests for autoimmune diseases," commented Stefan Eschbach, Vice President of Phadia. "The use of recombinant control antibodies was shown to increase the accuracy and reproducibility of diagnostic tests. AbD Serotec's ability to generate these highly-specific recombinant antibodies in various formats using the HuCAL technology has been extremely helpful in this regard." "Today's news marks the first market entry of a clinical diagnostic kit comprising a HuCAL antibody," commented Dr. Simon Moroney, Chief Executive Officer of MorphoSys. "This development is a significant step forwards for recombinant antibody technology in the diagnostics field, and a major operational milestone for our AbD unit."www.morphosys.com/en/news_investors/p...
MorphoSys Licenses RapMAT Technology to Astellas 07/23/2008 at 07:30 AM MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that Astellas Pharma Inc. has exercised a pre-existing option to use MorphoSys's proprietary RapMAT technology for faster antibody optimization as part of the existing technology transfer agreements between the two companies. As a result, Astellas will have access to MorphoSys's RapMAT technology module alongside the existing installation of the Company's proprietary antibody library HuCAL GOLD at Astellas' research site in Tsukuba, Japan. Under the extended agreement MorphoSys will receive annual user fees for the RapMAT technology and continues to receive annual user fees for access to its HuCAL platform. Further financial details were not disclosed. RapMAT, which stands for "rapid maturation", improves the options for identifying antibodies from the HuCAL libraries and reduces the time for generating promising therapeutic lead molecules. The RapMAT technology is completely compatible with the HuCAL GOLD antibody library. MorphoSys believes that the use of RapMAT can greatly speed up antibody drug discovery, while widening the pool of drug candidates from which to choose. "Today's news marks our second RapMAT-based technology deal with an existing partner. We welcome Astellas's decision to broaden its technological portfolio and use our RapMAT technology module to speed up their internal drug development process," commented Dr. Simon Moroney, Chief Executive Officer of MorphoSys. "Developments such as RapMAT are a result of our strategy to maintain our technological leadership in the field of human therapeutic antibodies, and thereby further strengthen our position in the market for this important class of drugs." www.morphosys.com/en/news_investors/p...
MorphoSys AG Reports Six Months 2008 Results 07/29/2008 at 07:30 AM Highlights of the Second Quarter of 2008: The phase 1 trial for MOR103 continues according to plan and is on track for completion and final reporting in Q1 2009. Partnered pipeline comprises 54 active therapeutic antibody projects (up from 50 at the end of 2007); number of pre-clinical candidates increased to 27. Extension of therapeutic partnerships with Schering-Plough and OncoMed. Boehringer Ingelheim exercised a pre-existing option to use MorphoSys's proprietary RapMAT technology for faster antibody optimization. Expansion of target sourcing network through research collaboration with the Berlin-based Leibniz-Institut für Molekulare Pharmakologie (FMP).www.morphosys.com/en/news_investors/p...
Research & Development / Alliance Management Progress Proprietary Pipeline MOR103 In April 2008, MorphoSys announced the completion of a first dosing regimen in a phase 1 clinical study on healthy volunteers of the HuCAL-derived antibody MOR103 with no adverse events reported. Six healthy volunteers in the first dosing group have been enrolled and received MOR103 injections, while three volunteers received placebo. The safety review of the medical data from the lowest dosing group yielded a determination that it was safe to proceed with the second dosing group. The randomized, double-blind, placebo-controlled, single-ascending dose trial will be conducted in approx. 50 healthy volunteers and is being conducted in a Clinical Pharmacology Unit (CPU) in Utrecht, the Netherlands. The trial is scheduled to be finalized in 2008 and final reporting is expected in Q1 2009. Strategy: Expansion of Proprietary Product Pipeline As announced earlier this year, MorphoSys remains committed to adding new programs to the existing proprietary projects MOR103 and MOR202. In that vein, during the first six months of the year, analysis and decisions have been made regarding the same. Emerging from this process, it was decided that the future growth of the Company’s proprietary pipeline will stem from three sources: de novo program starts based on our HuCAL technology, co-development projects and in-licensing activities relating to new programs. Progress Partnered Pipeline During the second quarter of 2008, no new programs were started. The two exclusive licenses acquired by OncoMed are not yet part of this calculation. MorphoSys’s existing partnered therapeutic antibody pipeline currently comprises 54 programs in total (up from 50 at the beginning of the year), of which currently 4 are in phase 1 clinical development, 27 in pre-clinical development, and 23 in research.212.14.81.205/uploads/MOR_Q2-2008_e_f...
MorphoSys Announces Publication of First MOR103 Data 09/02/2008 at 07:30 AM MOR103 anti-GM-CSF Antibody Shows Subpicomolar Affinity for its Target Molecule MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today the publication of a first data package for its most advanced proprietary drug development program MOR103, a fully human HuCAL antibody directed against GM-CSF, in the journal "Molecular Immunology". The data presented show that MOR103 is able to block disease-relevant processes such as GM-CSF dependent proliferation and signal transduction in vitro. Additionally, the publication describes that MorphoSys was able to achieve a 5,000-fold increase in affinity and a 2,000-fold increase in potency compared to the parental antibody using its established optimization technology. With a resulting affinity - or binding strength - of 400 femtomolar, MOR103 represents the first known anti-GM-CSF agent with a subpicomolar affinity for its target. Targeting of antigens, which are present only at low concentrations in patients such as GM-CSF, will require antibodies with low picomolar to subpicomolar affinities in order to reach efficacy in vivo at low dose levels. The high affinity is also expected to lead to a beneficial dosing regimen and cost of goods advantage. MOR103 is currently tested in a Phase 1 clinical trial to assess safety, tolerability and the pharmacokinetics of this fully human high affinity anti-GM-CSF HuCAL antibody. MorphoSys intends to present pre-clinical data for MOR103 at the HAH - Human Antibodies and Hybridomas Conference on November 12, 2008 in New York, USA, as well as at the IBC's 19th Annual International Antibody Engineering Conference on December 9, 2008 in San Diego, USA. "We are very pleased with the results we have seen so far with MOR103 and the generation process stands out as a showcase for MorphoSys's antibody generation capabilities using our HuCAL technology," commented Dr. Marlies Sproll, Chief Scientific Officer of MorphoSys. "While the antibody's affinity is merely one feature which influences its capability as a drug we believe based on the overall data we have generated so far that MOR103 represents a very promising therapeutic candidate in our pipeline." For further information please contact: Dr. Claudia Gutjahr-Löser, Head of Corporate Communications & Investor Relations, Tel: +49 (0) 89 / 899 27-122, gutjahr-loeser@morphosys.com or Mario Brkulj, Manager Corporate Communications & Investor Relations, Tel: +49 (0) 89 / 899 27-454, brkulj@morphosys.com About MOR103 to treat RA: Rheumatoid arthritis (RA) is traditionally considered a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints and affects in particular a membrane, called synovium, which lines each movable joint. It is a disabling and painful inflammatory condition, which can lead to substantial loss of mobility due to pain and joint destruction. As a systemic disease, RA often affects extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and muscles. The disease affects approximately 4-6 million people worldwide. In patients suffering from RA, white blood cells move from the bloodstream into the synovium. Here, these blood cells appear to play an important role in causing the synovial membrane to become inflamed. The HuCAL-based antibody MOR103 targets GM-CSF as a means to treat inflammatory diseases such as psoriasis, multiple sclerosis (MS), chronic obstructive pulmonary disease (COPD), asthma, and especially RA. The granulocyte macrophage colony-stimulating factor (GM-CSF) stimulates stem cells to produce granulocytes and other macrophages and subsequently activates these differentiated immune cells. GM-CSF is part of the natural immune and inflammatory cascade but has also been identified as an inflammatory mediator in autoimmune disorders like RA leading to an increased production of pro-inflammatory cytokines, chemokines and proteases and thereby ultimately to articular destruction. By neutralizing GM-CSF the HuCAL-based antibody MOR103 reduces undesired proliferation and activation of inflammatory granulocytes and macrophages and intervenes in several pathophysiological pathways. More information and picture material is available at: www.morphosys.com/en/mor103 www.morphosys.com/en/news_investors/p...
Sal. Oppenheim–European Healthcare Investors Conference 2008 September 3, 2008 MOR103 Proprietary Inflammation Programme Drug MOR103, a fully human IgG1 HuCAL antibody that binds GM-CSF with very high affinity Primary indication Rheumatoid arthritis, potential in asthma, COPD… Clinical Development Phase I study ongoing in Holland Approx. 50 healthy volunteers in a randomized, double-blind, placebo-controlled, single-ascending dose trial Safety, tolerability & pharmacokinetics Q4 2008: Publish pre-clinical data Q1 2009: Report Phase I results Strong IP Position Exclusive license to US patent application covering treatment of inflammation with inhibitors of GM-CSF Patent applications on the MOR103 antibody family MOR202: Proprietary Cancer Programme Drug MOR202, a fully human IgG1 HuCAL antibody that binds CD38, a marker on multiple myelomaand some leukemia cell-lines Primary indication Multiple myeloma Function Induces cell-killing by ADCC, CDC & apoptosis Development Timeline Q1 2008: Development candidate selected Q1 2008: Process development commenced Q1 -Q4 2009: Toxicology & safety Q1 2010: submit CTA Q2 2010: Commence Phase Iwww.morphosys.com/uploads/080903_Morp...
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Akka Technologies
AkzoNobel
Alfen
Allfunds Group
Allfunds Group
Almunda Professionals (vh Novisource)
Alpha Pro Tech
Alphabet Inc.
Altice
Alumexx ((Voorheen Phelix (voorheen Inverko))
AM
Amarin Corporation
Amerikaanse aandelen
AMG
AMS
Amsterdam Commodities
AMT Holding
Anavex Life Sciences Corp
Antonov
Aperam
Apollo Alternative Assets
Apple
Arcadis
Arcelor Mittal
Archos
Arcona Property Fund
arGEN-X
Aroundtown SA
Arrowhead Research
Ascencio
ASIT biotech
ASMI
ASML
ASR Nederland
ATAI Life Sciences
Atenor Group
Athlon Group
Atrium European Real Estate
Auplata
Avantium
Axsome Therapeutics
Azelis Group
Azerion
B&S Group
Baan
Ballast Nedam
BALTA GROUP N.V.
BAM Groep
Banco de Sabadell
Banimmo A
Barco
Barrick Gold
BASF SE
Basic-Fit
Basilix
Batenburg Beheer
BE Semiconductor
Beaulieulaan
Befimmo
Bekaert
Belgische aandelen
Beluga
Beter Bed
Bever
Binck
Biocartis
Biophytis
Biosynex
Biotalys
Bitcoin en andere cryptocurrencies
bluebird bio
Blydenstijn-Willink
BMW
BNP Paribas S.A.
Boeing Company
Bols (Lucas Bols N.V.)
Bone Therapeutics
Borr Drilling
Boskalis
BP PLC
bpost
Brand Funding
Brederode
Brill
Bristol-Myers Squibb
Brunel
C/Tac
Campine
Canadese aandelen
Care Property Invest
Carmila
Carrefour
Cate, ten
CECONOMY
Celyad
CFD's
CFE
CGG
Chinese aandelen
Cibox Interactive
Citygroup
Claranova
CM.com
Co.Br.Ha.
Coca-Cola European Partners
Cofinimmo
Cognosec
Colruyt
Commerzbank
Compagnie des Alpes
Compagnie du Bois Sauvage
Connect Group
Continental AG
Corbion
Core Labs
Corporate Express
Corus
Crescent (voorheen Option)
Crown van Gelder
Crucell
CTP
Curetis
CV-meter
CVC Capital Partners
Cyber Security 1 AB
Cybergun
D'Ieteren
D.E Master Blenders 1753
Deceuninck
Delta Lloyd
DEME
Deutsche Cannabis
DEUTSCHE POST AG
Dexia
DGB Group
DIA
Diegem Kennedy
Distri-Land Certificate
DNC
Dockwise
DPA Flex Group
Draka Holding
DSC2
DSM
Duitse aandelen
Dutch Star Companies ONE
Duurzaam Beleggen
DVRG
Ease2pay
Ebusco
Eckert-Ziegler
Econocom Group
Econosto
Edelmetalen
Ekopak
Elastic N.V.
Elia
Endemol
Energie
Energiekontor
Engie
Envipco
Erasmus Beursspel
Eriks
Esperite (voorheen Cryo Save)
EUR/USD
Eurobio
Eurocastle
Eurocommercial Properties
Euronav
Euronext
Euronext
Euronext.liffe Optiecompetitie
Europcar Mobility Group
Europlasma
EVC
EVS Broadcast Equipment
Exact
Exmar
Exor
Facebook
Fagron
Fastned
Fingerprint Cards AB
First Solar Inc
FlatexDeGiro
Floridienne
Flow Traders
Fluxys Belgium D
FNG (voorheen DICO International)
Fondsmanager Gezocht
ForFarmers
Fountain
Frans Maas
Franse aandelen
FuelCell Energy
Fugro
Futures
FX, Forex, foreign exchange market, valutamarkt
Galapagos
Gamma
Gaussin
GBL
Gemalto
General Electric
Genfit
Genmab
GeoJunxion
Getronics
Gilead Sciences
Gimv
Global Graphics
Goud
GrandVision
Great Panther Mining
Greenyard
Grolsch
Grondstoffen
Grontmij
Guru
Hagemeyer
HAL
Hamon Groep
Hedge funds: Haaien of helden?
Heijmans
Heineken
Hello Fresh
HES Beheer
Hitt
Holland Colours
Homburg Invest
Home Invest Belgium
Hoop Effektenbank, v.d.
Hunter Douglas
Hydratec Industries (v/h Nyloplast)
HyGear (NPEX effectenbeurs)
HYLORIS
Hypotheken
IBA
ICT Automatisering
Iep Invest (voorheen Punch International)
Ierse aandelen
IEX Group
IEX.nl Sparen
IMCD
Immo Moury
Immobel
Imtech
ING Groep
Innoconcepts
InPost
Insmed Incorporated (INSM)
IntegraGen
Intel
Intertrust
Intervest Offices & Warehouses
Intrasense
InVivo Therapeutics Holdings Corp (NVIV)
Isotis
JDE PEET'S
Jensen-Group
Jetix Europe
Johnson & Johnson
Just Eat Takeaway
Kardan
Kas Bank
KBC Ancora
KBC Groep
Kendrion
Keyware Technologies
Kiadis Pharma
Kinepolis Group
KKO International
Klépierre
KPN
KPNQwest
KUKA AG
La Jolla Pharmaceutical
Lavide Holding (voorheen Qurius)
LBC
LBI International
Leasinvest
Logica
Lotus Bakeries
Macintosh Retail Group
Majorel
Marel
Mastrad
Materialise NV
McGregor
MDxHealth
Mediq
Melexis
Merus Labs International
Merus NV
Microsoft
Miko
Mithra Pharmaceuticals
Montea
Moolen, van der
Mopoli
Morefield Group
Mota-Engil Africa
MotorK
Moury Construct
MTY Holdings (voorheen Alanheri)
Nationale Bank van België
Nationale Nederlanden
NBZ
Nedap
Nedfield
Nedschroef
Nedsense Enterpr
Nel ASA
Neoen SA
Neopost
Neovacs
NEPI Rockcastle
Netflix
New Sources Energy
Neways Electronics
NewTree
NexTech AR Solutions
NIBC
Nieuwe Steen Investments
Nintendo
Nokia
Nokia Oyj
Nokia OYJ
Novacyt
NOVO-NORDISK AS
NPEX
NR21
Numico
Nutreco
Nvidia
NWE Nederlandse AM Hypotheek Bank
NX Filtration
NXP Semiconductors NV
Nyrstar
Nyxoah
Océ
OCI
Octoplus
Oil States International
Onconova Therapeutics
Ontex
Onward Medical
Onxeo SA
OpenTV
OpGen
Opinies - Tilburg Trading Club
Opportunty Investment Management
Orange Belgium
Oranjewoud
Ordina Beheer
Oud ForFarmers
Oxurion (vh ThromboGenics)
P&O Nedlloyd
PAVmed
Payton Planar Magnetics
Perpetuals, Steepeners
Pershing Square Holdings Ltd
Personalized Nursing Services
Pfizer
Pharco
Pharming
Pharnext
Philips
Picanol
Pieris Pharmaceuticals
Plug Power
Politiek
Porceleyne Fles
Portugese aandelen
PostNL
Priority Telecom
Prologis Euro Prop
ProQR Therapeutics
PROSIEBENSAT.1 MEDIA SE
Prosus
Proximus
Qrf
Qualcomm
Quest For Growth
Rabobank Certificaat
Randstad
Range Beleggen
Recticel
Reed Elsevier
Reesink
Refresco Gerber
Reibel
Relief therapeutics
Renewi
Rente en valuta
Resilux
Retail Estates
RoodMicrotec
Roularta Media
Royal Bank Of Scotland
Royal Dutch Shell
RTL Group
RTL Group
S&P 500
Samas Groep
Sapec
SBM Offshore
Scandinavische (Noorse, Zweedse, Deense, Finse) aandelen
Schuitema
Seagull
Sequana Medical
Shurgard
Siemens Gamesa
Sif Holding
Signify
Simac
Sioen Industries
Sipef
Sligro Food Group
SMA Solar technology
Smartphoto Group
Smit Internationale
Snowworld
SNS Fundcoach Beleggingsfondsen Competitie
SNS Reaal
SNS Small & Midcap Competitie
Sofina
Softimat
Solocal Group
Solvac
Solvay
Sopheon
Spadel
Sparen voor later
Spectra7 Microsystems
Spotify
Spyker N.V.
Stellantis
Stellantis
Stern
Stork
Sucraf A en B
Sunrun
Super de Boer
SVK (Scheerders van Kerchove)
Syensqo
Systeem Trading
Taiwan Semiconductor Manufacturing Company (TSMC)
Technicolor
Tele Atlas
Telegraaf Media
Telenet Groep Holding
Tencent Holdings Ltd
Tesla Motors Inc.
Tessenderlo Group
Tetragon Financial Group
Teva Pharmaceutical Industries
Texaf
Theon International
TherapeuticsMD
Thunderbird Resorts
TIE
Tigenix
Tikkurila
TINC
TITAN CEMENT INTERNATIONAL
TKH Group
TMC
TNT Express
TomTom
Transocean
Trigano
Tubize
Turbo's
Twilio
UCB
Umicore
Unibail-Rodamco
Unifiedpost
Unilever
Unilever
uniQure
Unit 4 Agresso
Univar
Universal Music Group
USG People
Vallourec
Value8
Value8 Cum Pref
Van de Velde
Van Lanschot
Vastned
Vastned Retail Belgium
Vedior
VendexKBB
VEON
Vermogensbeheer
Versatel
VESTAS WIND SYSTEMS
VGP
Via Net.Works
Viohalco
Vivendi
Vivoryon Therapeutics
VNU
VolkerWessels
Volkswagen
Volta Finance
Vonovia
Vopak
Warehouses
Wave Life Sciences Ltd
Wavin
WDP
Wegener
Weibo Corp
Wereldhave
Wereldhave Belgium
Wessanen
What's Cooking
Wolters Kluwer
X-FAB
Xebec
Xeikon
Xior
Yatra Capital Limited
Zalando
Zenitel
Zénobe Gramme
Ziggo
Zilver - Silver World Spot (USD)
Indices
AEX
905,10
+0,16%
EUR/USD
1,0908
+0,56%
FTSE 100
8.262,75
-0,15%
Germany40^
18.571,90
-0,19%
Gold spot
2.350,30
+0,98%
NY-Nasdaq Composite
16.828,67
+0,56%
Stijgers
Dalers