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Home  /  Forum  /  Vivoryon Therapeutics  /  Vivoryon in 2024: Overname, Deal of Down the Drain?

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Aandeel VIVORYON THERAPEUTICS N.V. AEX:VVY.NL, NL00150002Q7

  • 0,761 3 mei 2024 17:35
  • +0,051 (+7,18%) Dagrange 0,696 - 0,786
  • 581.618 Gem. (3M) 757,7K

Vivoryon in 2024: Overname, Deal of Down the Drain?

803 Posts
Pagina: «« 1 ... 31 32 33 34 35 ... 41 »» | Laatste | Omlaag ↓
  4. forum rang 6 Rowi62 23 april 2024 09:14
    Ik kan dit alleen met pump en dump verklaren. Iemand met meerdere accounts die als koper en verkoper optreedt. Dat zag je vroeger ook meerdere malen gebeuren. Alleen nu is het nog risicovoller erin mee te gaan. Er is geen omzet en geen onderzoek meer dus dan is het als Galapagos. Cash opmaken en het licht uit. Daar zit DZR wel goed denk ik.
  17. forum rang 10 DeZwarteRidder 23 april 2024 10:05
    Vivoryon Therapeutics N.V. Provides Update on VIVIAD Phase 2b Study of Varoglutamstat in Early Alzheimer’s Disease

    VIVIAD Phase 2b study did not meet its primary and key secondary endpoints
    Varoglutamstat was generally well tolerated with low discontinuation rates due to adverse events and no evidence of symptomatic ARIAs in the clinical setting
    VIVIAD is a comprehensive, diligently designed and high-quality study; baseline demographics in the study were highly representative of early AD patient population
    Company is conducting an in-depth analysis of the results, including analyses of additional pre-specified and exploratory endpoints
    Further update expected to be provided no later than with publication of Company’s full year 2023 financial results

    Halle (Saale) / Munich, Germany, March 4, 2024 – Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) (Vivoryon), a clinical stage company focused on the discovery and development of small molecule medicines to modulate the activity and stability of pathologically altered proteins, today announced topline results from its Phase 2b European VIVIAD study of varoglutamstat (PQ912), an investigational oral glutaminyl cyclase (QPCT) inhibitor in development for the treatment of early Alzheimer’s disease (AD). The VIVIAD study did not meet its primary endpoint and did not show a statistically significant difference in change over time on cognition, as measured by a combined score (Z-score) of the Detection test, the Identification test and the ‘One Back’ test (attention and working memory domains) of the Cogstate neuropsychological test battery (NTB), called “Cogstate 3-item scale”. Additionally, the study did not meet key secondary endpoints measuring cognition (Cogstate Brief Battery, CBB, and complete Cogstate NTB), Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) and electroencephalogram (EEG) global theta power. Varoglutamstat was generally well tolerated and showed rates similar to placebo of serious and severe treatment emergent adverse events (TEAEs), low discontinuation rates due to adverse events and no evidence of symptomatic ARIAs (amyloid-related imaging abnormalities) in the clinical setting.

    The Company is conducting an in-depth analysis of the results, including analyses of additional pre-specified exploratory endpoints (e.g. WAIS-IV coding test, executive function and episodic memory domains, Winterlight Labs speech assessment, cerebrospinal fluid (CSF) biomarkers and additional EEG analysis) and distinct patient cohorts as defined in the statistical analysis plan, including ApoE4 status, tau level, dose level and pre-treatment.

    “We are profoundly disappointed by the outcome of the VIVIAD Phase 2b study of varoglutamstat in the early AD patient population given the huge unmet need for new safe and effective oral therapies,” said Frank Weber, M.D., CEO of Vivoryon. “I would like to express our gratitude to the patients, their families and caregivers, as well as the investigators for participating in the VIVIAD study, and to our incredible team at Vivoryon for their tireless efforts. While these results are not what we had hoped for, VIVIAD is a comprehensive, diligently designed and high-quality study and we are doing all we can to fully analyze the dataset as quickly as possible to gain insights into key findings that might influence varoglutamstat clinical development and help advance the science and understanding of this devastating disease.”

    A further update is expected to be provided no later than with the publication of the Company’s full year 2023 financial results which are expected in mid to late April 2024.
803 Posts
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VIVORYON THERAPEUTICS N.V. Nieuws

  1. 24 apr Vivoryon stopt eerder met studie naar middel tegen Alzheimer
  2. 16 apr Vivoryon publiceert cijfers 2023 eind april
  3. 26 mrt Warburgs vreselijke Vivoryon-misser
  4. 19 mrt Christiansen weer kleiner in Vivoryon 1
  5. 15 mrt Deel van commissarissen Vivoryon stapt op 1
  6. 09 mrt UBS kleiner in Vivoryon
  7. 06 mrt Aandeelhouder GS&P zegt vertrouwen in Vivoryon op
  8. 05 mrt Jefferies verlaagt koersdoel Vivoryon met 96% 2
  9. 04 mrt Koers Vivoryon implodeert 3
  10. 04 mrt Jefferies: oorwassing Vivoryon dreigt na mislukken alzheimerstudie

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